Anastrozole – Arimidex
Anastrozole is an extremely powerful anti-estrogen perhaps the most commonly used AI and one of the most common anti-estrogens on the market. Arimidex has proven to be very effective in breast cancer treatment, even more so than traditional Nolvadex (Tamoxifen Citrate), and is a favorite among many anabolic steroid users.
The functions of Arimidex although powerful are extremely simple. As an AI Arimidex functions by blocking the aromatase enzyme, which is in turn responsible for the production of estrogen. By inhibiting the aromatase process, Arimidex will lower the body’s serum estrogen levels; in fact, a total suppression of estrogen by 80% has been well noted with this AI. Arimidex also has the ability to stimulate the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), two hormones essential to natural testosterone production.
In recent years, Arimidex has become the leading anti-estrogen in the treatment of hormone receptor-positive breast cancer, especially among post-menopausal women. Once the cancer has subsided, it is not uncommon for Nolvadex to be introduced in order to keep the cancer at bay. For the anabolic steroid user, the effects of Arimidex are greatly appreciated in its ability to protect against estrogenic related side effects. Many anabolicsteroids have the ability to promote estrogenic side effects due to the testosterone hormone’s interaction with the aromatase enzyme.
By including Arimidex in an anabolic steroid cycle that contains aromatizing steroids, the individual can protect against gynecomastia and water retention. This will also protect against high blood pressure. Some steroids can still cause high blood pressure without water retention, but heavy excess water retention is the number one culprit of high blood pressure among anabolic steroid users. Without question, AI’s like Arimidex are the most effective anti-estrogens for combating estrogenic related side effects. SERM’s like Nolvadex can also be useful and while not as effective should be the first choice when possible.
Arimidex carries several possible side effects. Most anabolic steroid users will not have this issue with low dose Arimidex use. However, we can make an exception when it is used in hard cutting or competition cycles when calories are very low and training often extremely intense. Other possible side effects of Arimidex use include:
- Hot Flashes
- High Blood Pressure
- Joint Pain
- Depression (rare)
- Nausea and or Vomiting (rare)
In the treatment of breast cancer, Arimidex is almost always dosed at 1mg per day until the cancer subsides. Use may continue for a time at this stage and will often be switched to Nolvadex in a preventative measure once the cancer is in remission.
For the anabolic steroid user, Arimidex doses can vary with 0.5-1mg every other day being the most common. Very few should ever need more than 1mg every other day and many will be more than fine with half that amount. In therapeutic plans such as low testosterone treatment even less may be needed. We can, however, make an exception in Arimidex doses for competitive bodybuilders. Competitive bodybuilders may find a full 1mg every day the last 10-14 days leading up to competition to be useful. This will greatly aid in hardening, but it will be draining to say the least. Of course, at this stage of a competition diet most have very little energy to begin with anyway.